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Table 5.1 Percentage Reporting Negative Symptoms of GHQ 12 ; by Gender, Canadian Undergraduates, 2004.

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Intrapatient variability is postulated to be one of the limitations that makes the use of TDM unreliable in the management of antiretroviral therapy. Variability during various phases of the menstrual cycle has been described for ZDV and IDV75. These findings suggest that TDM is limited into a great extent, and that concentrations measured on one day may not be the same another day. The implications of these findings on TDM must be carefully evaluated. TDM in antiretroviral therapy requires a wide knowledge of drug pharmacokinetics and their interactions. For instance, food interactions seem to play an important role because they can modify the Cmax, AUC, Cmin and Tmax of any antiretroviral compounds. For example, food delays the Tmax for NFV and the concentration obtained before dosing might not be the lowest point in the dosage interval. Finally, sample timing is particularly important.

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